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As GABA and glutamate hold opposite effects modulating the neural activity (either decreasing or increasing excitability), it may be possible that the relation of these neurometabolites with GSH derives from the energy supply needed to hold either inhibitory or excitatory connections and not from the energy of neural activity itself

The Wegovy pill is started at the lowest therapeutic dose (1.5 mg), and its dosage is increased gradually until the 25 mg maximum dose is reached

GLP-1 Antagonists Explained A GLP-1 antagonist does the opposite job

The FASEB Journal, 21, 18441856

At 6 or 12 months, depending on the progress made, the doctor might recommend keeping the same dose if there is no slowing of the weight loss, or if there is no further improvement for some time, so you may be switched to a higher dose